Twenty One Hotel
23 Cola Di Rienzo Street, Vatican, Rome, Italy, 00192
Room Types
Available from Sat 25 Jul 2026 to Sun 26 Jul 2026
About This Hotel
Twenty One Hotel
You'll be sure to see the absolute most of sights in Rome when you stay at Twenty One Hotel, right in the heart of the city center near all the famous landmarks. The true local flavors and culture of Rome are yours with a stay at Twenty One Hotel, located just 2.8 km from the famous Colosseum.
Twenty One Hotel provides the best in services and amenities to help make guests feel comfortable. Stay connected throughout your stay with free internet access provided. To help pre-arrange your arrival and departure, airport transfer services can be booked before you even check in. Your explorations of Rome can be assisted with the shuttle services available here.
Parking is provided for guests by the hotel. You'll have no problem planning out your days and transportation needs with front desk services including concierge service, express check-in or check-out, luggage storage and safety deposit boxes. The hotel's ticket service and tours can even help you book tickets and reservations for entertainment and explorations. Wear your favorite outfits again and again thanks to the dry cleaning service and laundry service offered at Twenty One Hotel.
In-room conveniences such as 24-hour room service, room service and daily housekeeping will make staying in a great choice. The hotel is entirely non-smoking. Smoking may only take place in restricted designated areas.
Guestrooms are fitted with all the amenities you need for a good night's sleep. To enhance your stay, some rooms at the hotel come with linen service, blackout curtains and air conditioning. The specially-designed rooms at Twenty One Hotel offer a layout option like a balcony or terrace. Some rooms have cable TV to keep guests entertained.
You may be assured to know that a refrigerator, a coffee or tea maker and mini bar are available in some select rooms. You can stay fresh and clean with a hair dryer, toiletries, bathrobes and towels provided in some of the guest bathrooms.
Dining and things to do
Wake up with no worries at Twenty One Hotel, where breakfast can be provided in house. What's better than a good cup of coffee? Start every vacation day at the hotel with an energizing cup of quality coffee. Throughout your stay, choose from a variety of delicious dining options at the hotel. Once there, be sure to check out bar for some in-house nighttime fun.
Twenty One Hotel offers wonderful recreational facilities for guests to enjoy. Warm up at the end of the day with a visit to the salon. No need to go anywhere after dinner -- play with friends or family at the shared lounge and TV area. You can find a perfect memento of your trip, or grab some simple travel supplies at the shops.
Around the property
Venture outside Twenty One Hotel and explore Rome during your stay. Photograph yourself in front of Pantheon located 1.3 km away, which people travel great distances to see. Learn about the city's art history with a day at Galleria Borghese located 1.9 km away, where you can see collections by famous artists.
Reasons to stay here
Spend less here on rooms than you would at 97% of other accommodations in the city.
Verified reviews for this hotel's food and dining options score it better than 98% of accommodations in the city.
This accommodation beats more than 98% of competition in the city on room comfort.
What's Included
Check-in/Check-out
Extras
The property
Child Policies
Infant 0-1 year(s)
Stay for free if using existing bedding. Note, if you need a cot there may be an extra charge.
Children 2-3 year(s)
Stay for free if using existing bedding.
Facilities & Amenities
Highlights
360 meters to public transportation
Lepanto Underground Station is within 360 meters
Religious Places and Icons
Colosseum
Sights and Monuments
Location
23 Cola Di Rienzo Street, Vatican, Rome, Italy, 00192
Guest Reviews
Excellent
Guest score out of 10
“Positives: Great Location in upscale neighborhood with many good restaurants, cafes, pharmacies, shopping around.”
— Tucker , United States