Twenty One Hotel

23 Cola Di Rienzo Street, Vatican, Rome, Italy, 00192

Guests
Rooms
Adults
Children

Room Types

Available from Sat 25 Jul 2026 to Sun 26 Jul 2026

Junior Suite Junior Suite Junior Suite Junior Suite Junior Suite Junior Suite

Junior Suite

Room size: 25 m²/269 ft² Street view Balcony/terrace Non-smoking Shower and bathtub
2 guests
Double Double Double Double Double Double

Double

Room size: 18 m²/194 ft² Street view Balcony/terrace Non-smoking Shower
2 guests
Triple Triple Triple Triple Triple

Triple

Room size: 22 m²/237 ft² Street view Balcony/terrace Non-smoking Shower
2 guests
Twin Twin Twin

Twin

Room size: 18 m²/194 ft² Street view Balcony/terrace Non-smoking Shower
2 guests
Double for Single Use Double for Single Use Double for Single Use

Double for Single Use

Room size: 18 m²/194 ft² Street view Non-smoking Shower
2 guests
Family Room (4 Adults) Family Room (4 Adults) Family Room (4 Adults) Family Room (4 Adults) Family Room (4 Adults)

Family Room (4 Adults)

Room size: 29 m²/312 ft² Shower and bathtub
4 guests
Double for Single Use

Double for Single Use

Room size: 18 m²/194 ft² Street view
2 guests
Room Assigned on Arrival

Room Assigned on Arrival

Balcony/terrace Shower
2 guests

About This Hotel

Twenty One Hotel

Twenty One Hotel

You'll be sure to see the absolute most of sights in Rome when you stay at Twenty One Hotel, right in the heart of the city center near all the famous landmarks. The true local flavors and culture of Rome are yours with a stay at Twenty One Hotel, located just 2.8 km from the famous Colosseum.
Twenty One Hotel provides the best in services and amenities to help make guests feel comfortable. Stay connected throughout your stay with free internet access provided. To help pre-arrange your arrival and departure, airport transfer services can be booked before you even check in. Your explorations of Rome can be assisted with the shuttle services available here.
Parking is provided for guests by the hotel. You'll have no problem planning out your days and transportation needs with front desk services including concierge service, express check-in or check-out, luggage storage and safety deposit boxes. The hotel's ticket service and tours can even help you book tickets and reservations for entertainment and explorations. Wear your favorite outfits again and again thanks to the dry cleaning service and laundry service offered at Twenty One Hotel.
In-room conveniences such as 24-hour room service, room service and daily housekeeping will make staying in a great choice. The hotel is entirely non-smoking. Smoking may only take place in restricted designated areas.
Guestrooms are fitted with all the amenities you need for a good night's sleep. To enhance your stay, some rooms at the hotel come with linen service, blackout curtains and air conditioning. The specially-designed rooms at Twenty One Hotel offer a layout option like a balcony or terrace. Some rooms have cable TV to keep guests entertained.
You may be assured to know that a refrigerator, a coffee or tea maker and mini bar are available in some select rooms. You can stay fresh and clean with a hair dryer, toiletries, bathrobes and towels provided in some of the guest bathrooms.


Dining and things to do

Wake up with no worries at Twenty One Hotel, where breakfast can be provided in house. What's better than a good cup of coffee? Start every vacation day at the hotel with an energizing cup of quality coffee. Throughout your stay, choose from a variety of delicious dining options at the hotel. Once there, be sure to check out bar for some in-house nighttime fun.
Twenty One Hotel offers wonderful recreational facilities for guests to enjoy. Warm up at the end of the day with a visit to the salon. No need to go anywhere after dinner -- play with friends or family at the shared lounge and TV area. You can find a perfect memento of your trip, or grab some simple travel supplies at the shops.


Around the property

Venture outside Twenty One Hotel and explore Rome during your stay. Photograph yourself in front of Pantheon located 1.3 km away, which people travel great distances to see. Learn about the city's art history with a day at Galleria Borghese located 1.9 km away, where you can see collections by famous artists.


Reasons to stay here

Spend less here on rooms than you would at 97% of other accommodations in the city.
Verified reviews for this hotel's food and dining options score it better than 98% of accommodations in the city.
This accommodation beats more than 98% of competition in the city on room comfort.

What's Included

Check-in/Check-out

Check-in from: 14:00
Check-out until: 11:00

Extras

Breakfast charge (unless included in room price): 10 EUR

The property

Number of floors: 5
Number of rooms: 86
Room voltage: 220
Year property opened: 2010

Child Policies

Infant 0-1 year(s)

Stay for free if using existing bedding. Note, if you need a cot there may be an extra charge.

Children 2-3 year(s)

Stay for free if using existing bedding.

Facilities & Amenities

Balcony/terrace
Bar/lounge
Bathroom
Facilities
Shared lounge/TV area
Shower
Free WiFi Available throughout
Activities Tennis, Sauna, Gym
Parking Nearby available

Highlights

360 meters to public transportation

Lepanto Underground Station is within 360 meters

Religious Places and Icons

Colosseum

Sights and Monuments

Location

23 Cola Di Rienzo Street, Vatican, Rome, Italy, 00192

Guest Reviews

8.2

Excellent

Guest score out of 10

“Positives: Great Location in upscale neighborhood with many good restaurants, cafes, pharmacies, shopping around.”

— Tucker , United States